Found in strawberries. 10x more potent than quercetin in mice. Mayo Clinic's AFFIRM trial is testing fisetin as a senolytic for age-related decline.
Last updated: March 2026
Fisetin is a flavonol found in strawberries, apples, persimmons, and grapes. It's been studied for decades as an anti-inflammatory and neuroprotective compound. More recently, it's emerged as one of the most potent natural senolytics — 10x more effective at clearing senescent cells than quercetin.
10x more potent than quercetin at inducing apoptosis in senescent cells. Works through different pathways than D+Q, making it complementary.
Crosses the blood-brain barrier. Protects neurons from oxidative stress. Being studied for Alzheimer's and Parkinson's.
Mayo Clinic's AFFIRM trial is testing fisetin as a senolytic. First results expected soon. This is the rigorous human data the field needs.
Like other senolytics, fisetin works best intermittently. High dose once, then weeks off. Allows new senescent cells to accumulate.
Key insight: Fisetin's advantage is that it's a natural compound available as a supplement while having pharmaceutical-level potency. No prescription needed.
• Fisetin is a food compound with good safety profile
• High doses may cause GI upset
• May interact with blood thinners
• Limited data in pregnancy
Dosing schedules, interaction warnings, and cycle protocols for 50+ compounds — all in one place.
This page is for educational purposes only. Not medical advice. Fisetin is a dietary supplement. Consult a healthcare provider.