Last updated: March 2026
Follistatin is a naturally occurring glycoprotein that binds and neutralizes myostatin — the protein that limits muscle growth. In the famous Schwarzenegger mice experiments, mice lacking myostatin or treated with follistatin developed 2–3x normal muscle mass. Follistatin-344, the 344-amino acid isoform with the longest half-life, is the most researched form for muscle growth applications.
Follistatin is a naturally occurring glycoprotein that binds to and inhibits myostatin — a negative regulator of muscle growth. By neutralizing myostatin, follistatin removes the "brake" on muscle development.
Follistatin binds to myostatin with high affinity, preventing it from activating its receptors and inhibiting muscle growth.
With myostatin blocked, muscles grow beyond normal limits. This has been demonstrated in multiple animal models.
Most research focuses on gene therapy delivery (e.g., Myos Corporation). The protein itself has stability issues.
Mice lacking myostatin or treated with follistatin develop 2-3x normal muscle mass, becoming famous in research.
Animal data on follistatin and muscle growth.
Third-party tested compounds from Swiss Chems — one of the most trusted research suppliers.
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This page is for educational purposes only. Follistatin is not FDA approved. All research is preclinical or animal studies. Always consult a healthcare provider.