Last updated: March 2026
Humanin is a 24-amino acid peptide encoded by mitochondrial DNA — the first discovered mitochondrial-derived peptide (MDP), identified in 2001. It exhibits cytoprotective, anti-apoptotic, and insulin-sensitizing properties across multiple cell types. Circulating humanin levels decline with age, making it a candidate biomarker for biological aging and metabolic health.
Humanin is the first discovered mitochondrial-derived peptide (MDP) — encoded by mitochondrial DNA, not nuclear DNA.
A 24-amino acid peptide encoded by the mitochondrial genome — one of only a handful of known peptides derived from mtDNA.
Protects cells from various apoptotic triggers including amyloid-beta toxicity, ischemia/reperfusion injury, and oxidative stress.
Improves insulin sensitivity and glucose metabolism. Shows promise in diabetes and metabolic syndrome models.
Demonstrated protective effects against cardiac ischemia and vascular endothelial dysfunction.
Preclinical data on Humanin's mechanisms.
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This page is for educational and informational purposes only. Humanin is a research peptide not approved by the FDA or any regulatory body. All data comes from preclinical studies (cell culture and animal models). No human clinical trials have been completed. Always consult a qualified healthcare provider before starting any new substance.