Last updated: March 2026
Melanotan II is a synthetic analog of α-MSH (alpha-melanocyte-stimulating hormone), developed at the University of Arizona to stimulate melanin production for UV-free tanning by targeting melanocortin receptors MC1-R through MC5-R. Research dosing typically begins at 500 mcg subcutaneously. It is also the precursor to PT-141 (Bremelanotide), now FDA-approved for sexual dysfunction.
Melanotan II is a synthetic peptide analog of α-MSH (alpha-melanocyte-stimulating hormone). Developed at the University of Arizona, it stimulates melanocortin receptors to produce melanin and darken skin without UV exposure.
Stimulates melanocytes to produce eumelanin, providing a tan without UV exposure. Useful for people who can't tan normally.
Binds to melanocortin receptors (MC1R-MC5R) with varying affinity. MC1R is primarily responsible for melanin production.
Melanotan II's sexual function effects led to the development of PT-141 (Bremelanotide) — FDA approved for hypoactive sexual desire disorder.
Typically administered via subcutaneous injection. Nasal spray formulations have also been used in research.
Known side effects and concerns with Melanotan II use.
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This page is for educational purposes only. Melanotan II is not FDA approved. It is a research chemical with significant side effects. Always consult a healthcare provider.