The polyphenol from red wine that started the longevity revolution. Activates SIRT1, inhibits NF-κB, and mimics calorie restriction at the cellular level. 70+ clinical trials.
Last updated: March 2026
Resveratrol is a polyphenol found in grape skins, red wine, berries, and peanuts. It gained fame through David Sinclair's research at Harvard, showing it activates sirtuin genes (SIRT1) and extends lifespan in yeast. It became the flagship compound of the longevity movement.
Activates the SIRT1 gene, a key regulator of cellular aging. SIRT1 controls mitochondrial function, DNA repair, and stress resistance. Resveratrol directly activates SIRT1, mimicking calorie restriction benefits.
Powerful anti-inflammatory effects through NF-κB inhibition. Reduces TNF-α, IL-6, and other pro-inflammatory cytokines. May be as important as SIRT1 activation.
Activates AMPK (AMP-activated protein kinase) — the cellular energy sensor. Increases glucose uptake, improves insulin sensitivity, boosts mitochondrial biogenesis.
Found in grape skins (concentration increases with fungal infection — hence red wine). You'd need ~100 glasses for therapeutic dose — supplements are necessary.
Key insight: The "French Paradox" (low heart disease despite high fat diet) was initially attributed to resveratrol in red wine. While the dose connection was overstated, the mechanistic research opened an entire field.
Tip: Pterostilbene (a resveratrol analog) has 4x bioavailability. Many stacks combine resveratrol + pterostilbene for better effect.
• GI upset: Nausea, diarrhea at high doses
• Headaches: Occasionally reported
• Drug interactions: May interact with blood thinners (warfarin), NSAIDs
• Pregnancy: Avoid during pregnancy (insufficient data)
Dosing schedules, interaction warnings, and cycle protocols for 50+ compounds — all in one place.
This page is for educational purposes only. Not medical advice. Consult a healthcare provider before starting any supplement.