Last updated: March 2026
SR-9009 (Stenabolic) is a Rev-Erbα agonist — not a SARM — developed at Scripps Research. It modulates circadian biology, mitochondrial biogenesis, and fat oxidation. Often called an "exercise mimetic." Critical caveat: its oral bioavailability in animals is extremely poor. All data from preclinical animal studies.
SR-9009 activates Rev-Erbα, a nuclear receptor that acts as a transcription repressor controlling circadian clock genes. By activating Rev-Erbα, SR-9009 alters the expression of hundreds of metabolic genes — influencing fat oxidation, glucose metabolism, mitochondrial density, and inflammatory pathways.
Rev-Erbα (NR1D1) is a nuclear receptor that represses clock gene expression, regulating the body's circadian rhythm. SR-9009 binds and activates Rev-Erbα, modulating the transcription of BMAL1, CLOCK, and downstream metabolic genes. This shifts the cell's perceived metabolic state.
In mouse models, SR-9009 treatment increased the number of mitochondria in skeletal muscle and enhanced oxidative capacity. This is the basis for its "exercise mimetic" designation — more mitochondria means greater fat-burning capacity, even at rest. Data is exclusively from animal models.
Activated Rev-Erbα represses fatty acid synthesis genes and upregulates fat oxidation pathways. In diet-induced obese mice, SR-9009 reduced fat mass without changes to food intake. Glucose uptake and utilization were also improved. These effects were demonstrated via intraperitoneal injection, not oral dosing.
Animal studies measuring SR-9009's pharmacokinetics found oral bioavailability to be less than 2%. The vast majority of SR-9009 research used intraperitoneal injection directly into the abdominal cavity. Oral formulations in humans may deliver negligible systemic compound. This is a fundamental limitation of the oral use case.
⚠️ All data below is from animal studies (mouse/rodent models), administered primarily via intraperitoneal injection — NOT oral dosing. These findings may not translate to oral human use.
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This page is for educational purposes only. It is not medical advice. SR-9009 is not FDA approved and is not intended for human use. All efficacy data is from preclinical animal studies using injection protocols. Oral use in humans may deliver negligible active compound. Do not use any research chemical without consulting a qualified medical professional.