Question 1

What is the standard semaglutide (Ozempic) titration schedule?

Accepted Answer

The standard semaglutide titration starts at 0.25 mg weekly for weeks 1–4, increases to 0.5 mg for weeks 5–8, then 1 mg for weeks 9–12, 1.7 mg for weeks 13–16, and reaches the maintenance dose of 2.4 mg thereafter. Each dose is administered as a weekly subcutaneous injection.

Question 2

How long does it take to reach the full dose of tirzepatide (Mounjaro)?

Accepted Answer

Tirzepatide titration typically takes 20 weeks to reach the maximum dose of 15 mg. It starts at 2.5 mg weekly, increasing every 4 weeks through 5 mg, 7.5 mg, 10 mg, and 12.5 mg before reaching 15 mg maintenance.

Question 3

Why do GLP-1 medications require dose titration?

Accepted Answer

GLP-1 receptor agonists require gradual dose titration to minimize gastrointestinal side effects such as nausea, vomiting, and diarrhea. Starting at a lower dose allows the body to adapt to the medication before increasing to therapeutically effective levels.

Question 4

Can I start a GLP-1 medication at a higher dose if I've used one before?

Accepted Answer

Restarting at a higher dose depends on how long you've been off the medication and your healthcare provider's guidance. Generally, if you've been off for more than a few weeks, re-titration from a lower dose is recommended to minimize side effects. Always consult your prescribing physician.

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