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đ Tirzepatide Dose Calculator
Vial Size (mg)
5 mg
10 mg
15 mg
30 mg
Bacteriostatic Water Added (mL)
1 mL
2 mL
3 mL
Target Dose (mg)
2.5 mg (starting)
5 mg
7.5 mg
10 mg
12.5 mg
15 mg (max)
Inject this amount:
50 units
(0.50 mL)
âī¸ Compare Weight Loss Peptides
đ Tirzepatide Titration Schedule
Week
Dose
Notes
1-4
2.5 mg
Starting dose, GI adjustment
5-8
5 mg
First increase
9-12
7.5 mg
Continue if tolerated
13-16
10 mg
Many stay here
17-20
12.5 mg
If additional effect needed
21+
15 mg
Maximum dose
âī¸ Tirzepatide vs Semaglutide
Key Finding: In clinical trials, tirzepatide showed approximately 5-7% greater weight loss than semaglutide at comparable doses.
Tirzepatide
Dual GIP + GLP-1 agonist
Average weight loss: ~20-22%
Weekly injection
Doses: 2.5-15 mg
Brands: Mounjaro, Zepbound
Semaglutide
GLP-1 agonist only
Average weight loss: ~15%
Weekly injection
Doses: 0.25-2.4 mg
Brands: Ozempic, Wegovy
Why Might Tirzepatide Work Better?
The addition of GIP receptor activation may:
Enhance insulin secretion more effectively
Provide additional appetite suppression pathways
Improve glucose metabolism through multiple mechanisms
đ§Ŧ What is Tirzepatide?
Tirzepatide is the first dual GIP/GLP-1 receptor agonist. It activates TWO incretin hormone receptors instead of just one.
Mechanism of Action
GLP-1 activation: Slows gastric emptying, reduces appetite, improves insulin sensitivityGIP activation: Enhances insulin release, may provide additional metabolic benefitsDual action: The combination appears synergistic for weight loss
Brand Names
Mounjaro â FDA-approved for type 2 diabetesZepbound â FDA-approved for weight loss
⥠Side Effects
Similar profile to semaglutide, generally comparable or slightly better tolerated:
Nausea â Most common, usually improvesDiarrhea â Common initiallyConstipation â Some experience this insteadDecreased appetite â The intended effectInjection site reactions â Usually mild
â ī¸ Same Warnings Apply:
Thyroid C-cell tumor warning (rodent studies)
Avoid if history of medullary thyroid cancer or MEN 2
Monitor for pancreatitis symptoms
May affect gallbladder
đ Supplies You'll Need
Essential supplies for reconstitution and injection:
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âšī¸ Disclaimer: This information is for educational and research purposes only. Tirzepatide is a prescription medication. Always consult with a healthcare provider.